The US government wastes $4.9T annually—17% of GDP. The Pentagon can't find $2.5T of its own assets. Americans spend 7.9 billion hours doing taxes. Systems engineering says we can fix this.
The Declaration of Optimization
Governments were created to promote the general welfare.
Instead, since 1913, these governments have printed $170T out of nothing and used it to murder 310 million people and destroy many of the valuable things those humans spent their entire lives building.
These murdered humans include approximately 930,000 physicians, 310,000 scientists, 620,000 engineers, and 102 million children who will never grow up to replace them.
That $170T could have funded 37.8 thousand years of clinical trials at current government spending.
These governments currently have enough weapons to murder every man, woman, and child on earth 20 times over, when once should be more than sufficient.
Yet despite this clearly adequate apocalypse capacity, they still spend 604 dollars on weapons for every dollar they spend on clinical trials to treat and cure disease.
Your chance of being killed by a terrorist? 1 in 30 million. Your chance of dying of a disease? 100%.
Had someone properly aligned your governments to maximize median healthy life years and median after-tax inflation-adjusted income in 1900, you would be 23.2x richer today and significantly less diseased.
This Declaration asks every nation on Earth to sign a treaty redirecting one percent of military spending to clinical trials. One percent.
Think about someone you love who is suffering right now. The treatment that would help them exists as an untested compound on a shelf, because the money bought a missile instead. That missile incinerated a child who would have grown up to discover the cure. You lose the treatment. You lose the scientist. You get the tax bill. You get to pay for her murder.
This is suboptimal.
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What if we took 1% of global military spending ($27.2B/year) and used it to actually save lives? 10.7 billion deaths averted. The maths checks out. The species does not.
Drug development costs increased 105x since 1962. Before regulations, drugs cost $24.7M to develop. Now it's $2.6 billion. The pills haven't gotten 105 times better.
The FDA's efficacy testing kills 3,070 people for every 1 it saves. 102 million dead since 1962. That's 17 Holocausts, but with better paperwork.
Stage 1 costs 10 cents per patient. Stage 2 costs $929. Traditional trials cost $41,000. That's a 44x reduction. The drugs don't know the difference.
6,650 diseases have zero FDA-approved treatments. Pragmatic trials cost $929 vs $41,000. Scale them up and you get $0.84 per DALY. That's cheaper than a Mars bar. Why haven't we done this?
86% of patients are excluded from clinical trials. 95% of rare diseases have zero FDA-approved treatments. The Right to Trial Act says: what if sick people could try things? Controversial.
Harvard study shows 3.5% active participation changes society. Not clicking "like." Actual showing up. Your government publishes the percentage needed.
FDA banned monoclonal antibodies despite 30% efficacy. They ignored $3.7T Long COVID cost, risked $600M in preventable hospitalizations.
Princeton study shows 90% of Americans have zero impact on legislation. 0% or 100% support both equal 30% passage chance. Democracy is flat line.