How decentralized physician trials from 1883-1962 achieved 4 years/decade life expectancy gains, and what happened when the 1962 regulations replaced them with industry-controlled trials
Think by Numbers runs cost-benefit analyses for a species that spends $604 on weapons for every $1 on clinical trials. We suspect a math error.
Posts, Ranked by Extinction-Prevention Potential
A comprehensive breakdown of how little humanity invests in not dying, distinguishing broad "research" from actual cures.
Your brain decided 10 seconds before you did. Brain scans prove you're not actually making choices.
US spends 37% of global military budget with 4.4% of world population. $600 billion on weapons. Switzerland makes chocolate instead.
The Optimal Policy Generator (OPG) produces systematic public policy recommendations for jurisdictions at any level (country, state, city), generating prioritized enact/replace/repeal/maintain recommendations to maximize real after-tax median income growth and median healthy life years, based on quasi-experimental evidence from centuries of policy variation data.
The Optimal Budget Generator (OBG) uses causal inference, diminishing returns modeling, and cost-effectiveness evidence to determine optimal public goods funding levels that maximize two terminal general-welfare metrics: real after-tax median income growth and median healthy life years. For each spending category, OBG estimates an Optimal Spending Level (OSL) and produces a gap analysis showing where current government budgets are over- or underfunded relative to evidence-based benchmarks. The Budget Impact Score (BIS) measures confidence in each recommendation based on the quality of causal evidence.
A policy-neutral protocol combining five primitives (transparent ledger, preference aggregation, evidence engine, identity verification, rules-based monetary policy) to replace mechanical government functions, return diverted value to citizens, and stop spending 17.3% of GDP on humans executing functions that are algorithmic in nature, while preserving democratic control over policy ends.
Your politicians are funded by the people they're supposed to regulate. Wishonia replaces campaign finance with a single alignment score.
Twelve humans around a table decide what your money is worth. The replacement is one formula, and it cannot be lobbied, panicked, or invited to Jackson Hole.
Your SEC protects you from the best-returning asset class unless you are already rich. The replacement protects you with information instead of exclusion.